Ultrasound-guided percutaneous microwave ablation for adenomyosis: efficacy of treatment and effect on ovarian function (Mar 2015)

Ultrasound-guided percutaneous microwave ablation for adenomyosis: efficacy of treatment and effect on ovarian function
Scientific Reports 5, Article number: 10034
Yu Y1, Jing Z2, Zhi-Yu H2, Xia M1, Yan-Li H2, Chang-Tao X2, Rui-Fang X2, Bing-Song Z2.
Author(s) affiliation:
1Department of Interventional Ultrasound, Chinese PLA General Hospital [2] Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University. (This study was performed at Chinese PLA General Hospital).
2Department of Interventional Ultrasound, Chinese PLA General Hospital.


Short description:
Adenomyosis is a common disease among women of childbearing age. Menorrhagia and dysmenorrhea are two of the most common symptoms and always require clinical intervention. Suppressive hormonal treatments can temporarily relieve symptoms, but these treatments interfere with patient fertility. Hysterectomy is the standard treatment for adenomyosis but may not be accepted by every patient of reproductive age.
Link to the journal


Abstract taken from PubMed

A total of 142 premenopausal women with symptomatic adenomyosis underwent ultrasound (US)-guided percutaneous microwave ablation (PMWA) at the Chinese PLA General Hospital. This study aimed to evaluate changes in serum pituitary, gonadal hormone and cancer antigen 125 (CA125) levels after US-guided PMWA. Therefore, estradiol (E2), follicle-stimulating hormone (FSH), prolactin (PRL) and CA125 levels were evaluated before ablation and at 3, 6, 9 and 12 months after ablation. No significant differences were observed in the E2 and FSH levels pre-ablation and during follow-up (E2: p = 0.933, p = 0.987, p = 0.106, p = 0.936; FSH: p = 0.552, p = 0.295, p = 0.414, p = 0.760). The mean absolute values of serum CA125 and PRL were significantly decreased at 3, 6, 9 and 12 months after ablation (CA125: p < 0.001, p < 0.001, p < 0.001, p = 0.003; PRL: p < 0.001, p < 0.001, p < 0.001, p < 0.001). A significant correlation between changes in CA125 levels and uterine volume was found (p < 0.001). No evidence of a decline in ovarian function was observed after US-guided PMWA.
Link to the paper on PubMed

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