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Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization (Jun 2016)

science
Title:
Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization
Journal:
Science 23 Jun 2016: DOI: 10.1126
Author(s):
Zhou Q1, Li H1, Li H2, Nakagawa A1, Lin JL3, Lee ES1, Harry BL4, Skeen-Gaar RR1, Suehiro Y5, William D6, Mitani S5, Yuan HS3, Kang BH7, Xue D8
Author(s) affiliation:
1Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
2Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA. Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.
3Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.
4Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA. Medical Scientist Training Program, University of Colorado, Aurora, CO 80045, USA.
5Department of Physiology, Tokyo Women's Medical University, School of Medicine and CREST, Japan Science and Technology Agency, Tokyo 162-8666, Japan.
6Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611, USA.
7School of Life Sciences, Centre for Cell and Developmental Biology and State Key Laboratory of Agrobiotechnology, Chinese University of Hong Kong, Hong Kong, China. This email address is being protected from spambots. You need JavaScript enabled to view it. This email address is being protected from spambots. You need JavaScript enabled to view it..
8Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA. This email address is being protected from spambots. You need JavaScript enabled to view it. This email address is being protected from spambots. You need JavaScript enabled to view it.
 

 

Short description:
Mitochondria are inherited maternally in most animals, but the mechanisms of selective paternal mitochondrial elimination (PME) are unknown. While examining fertilization in C. elegans, we observe that paternal mitochondria rapidly lose their inner membrane integrity. CPS-6, a mitochondrial endonuclease G, serves as a paternal mitochondrial factor that is critical for PME. The CPS-6 endonuclease relocates from the intermembrane space of paternal mitochondria to the matrix following fertilization to degrade mitochondrial DNA. It acts with maternal autophagy and proteasome machineries to promote PME. Loss of cps-6 delays breakdown of mitochondrial inner membranes, autophagosome enclosure of paternal mitochondria, and PME. Delayed removal of paternal mitochondria causes increased embryonic lethality, demonstrating that PME is important for normal animal development. Thus, CPS-6 functions as a paternal mitochondrial degradation factor during animal development.
Link to the journal
 

 

Abstract taken from PubMed

Abstract:
Mitochondria are inherited maternally in most animals, but the mechanisms of selective paternal mitochondrial elimination (PME) are unknown. While examining fertilization in C. elegans, we observe that paternal mitochondria rapidly lose their inner membrane integrity. CPS-6, a mitochondrial endonuclease G, serves as a paternal mitochondrial factor that is critical for PME. The CPS-6 endonuclease relocates from the intermembrane space of paternal mitochondria to the matrix following fertilization to degrade mitochondrial DNA. It acts with maternal autophagy and proteasome machineries to promote PME. Loss of cps-6 delays breakdown of mitochondrial inner membranes, autophagosome enclosure of paternal mitochondria, and PME. Delayed removal of paternal mitochondria causes increased embryonic lethality, demonstrating that PME is important for normal animal development. Thus, CPS-6 functions as a paternal mitochondrial degradation factor during animal development.
Link to the paper on PubMed
 




 

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