Are you transferring aneuploid/mosaic embryo?

Dear Colleague,

We are inviting you to participate in a worldwide survey relating to the practice of preimplantation genetic screening (PGS), recently called preimplantation genetic testing for aneuploidy (PGT-A). The primary purpose of this survey is to gather data on how popular the transfer of “abnormal” embryos has become after the International Preimplantation Diagnosis International Society (PGDIS) in July of 2016 modified reporting guidelines for PGS/PGT-A laboratories, and for the first time allowed selective transfers of what the society defined as “mosaic” embryos.

So far published data suggest establishment of at least 100 ongoing pregnancies worldwide through transfer of embryos reported as “abnormal-aneuploid” or “mosaic” by PGS/PGT-A. So-called “mosaic” embryos, which before publication of the new guidelines were uniformly considered “aneuploid,” since then are labeled as “mosaic” embryos if aneuploid DNA load in a single trophectoderm biopsy is measured at 21-80% of total DNA load. Only if aneuploid DNA load is >80%, are embryos now reported as “aneuploid-abnormal.”.

If your center has not performed transfers of “abnormal” embryos, your participation in this survey will be very brief, and will involve only at most 4 questions. We, still, very much would appreciate your participation since we are very interested in finding out how quickly this recommended practice change has been accepted in the worldwide IVF community.

If you have performed such transfers, please complete the whole survey.

Sincerely,
Pasquale Patrizio USA and Norbert Gleicher, USA

Personal data is collected only to ensure the accuracy and authenticity of the clinical data submitted and generated. Personal data will not be published.