Cryopreservation of Oocytes (Oct 2015)

nejm
Title:
Cryopreservation of Oocytes
Journal:
N Engl J Med 2015; 373:1755-1760October 29, 2015DOI: 10.1056/NEJMcp1307341
Author(s):
Glenn L. Schattman, M.D.
Author(s) affiliation:
Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College–Weill Cornell Medical Center, York Ave., New York, NY
 

 

THE CLINICAL PROBLEM:
Women have a finite pool of oocytes that decreases throughout their reproductive years, with fewer than 1000 eggs remaining at the onset of menopause (mean age, 51.2 years).1 Although women continue to ovulate until menopause, fecundity (the probability of achieving pregnancy in each cycle) diminishes as they age because of increasing rates of aneuploidy in association with older oocytes. In a study involving women who received up to 12 cycles of insemination with donor sperm, 74% of women younger than 31 years of age conceived, as compared with 54% of women older than 35 years of age.2 Thus, older women who are attempting to start families have a higher probability of remaining involuntarily childless.3
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