Cryopreservation of Oocytes
N Engl J Med 2015; 373:1755-1760October 29, 2015DOI: 10.1056/NEJMcp1307341
Glenn L. Schattman, M.D.
Author(s) affiliation:
Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College–Weill Cornell Medical Center, York Ave., New York, NY


Women have a finite pool of oocytes that decreases throughout their reproductive years, with fewer than 1000 eggs remaining at the onset of menopause (mean age, 51.2 years).1 Although women continue to ovulate until menopause, fecundity (the probability of achieving pregnancy in each cycle) diminishes as they age because of increasing rates of aneuploidy in association with older oocytes. In a study involving women who received up to 12 cycles of insemination with donor sperm, 74% of women younger than 31 years of age conceived, as compared with 54% of women older than 35 years of age.2 Thus, older women who are attempting to start families have a higher probability of remaining involuntarily childless.3
Link to the journal endeavors to ensure that the information in this article is accurate,reliable and up to date. However, the information is provided "as is" without warranty of any kind. IVF-Worldwide does not accept any responsibility or liability for the accuracy,content, completeness, legality, or reliability of the information contained in this article. is not responsible for the content of other websites linked to or referenced from this website. The website does not endorse the information, content,presentation or accuracy of such other websites and does not make any warranty,express or implied, regarding them.