majority (75%) reported that the data available in the literature is
insufficient to reach a decision concerning efficacy of the treatment.
Indications for treatment based on the survey
Poor-responder patients and
also serve as indications for Metformin use.
Glucose is measured by 66% of the reporting centers before initiating Metformin. Those who measure insulin consider high insulin as an indication for Metformin.
Glucose insulin ratio was not measured in most cases. However, those who observed this ratio accepted that less than 4.5 is suggestive of insulin resistance.
When to start treatment and the preferable dose
Follow-up of treatment
How long should treatment continue?
The majority continue treatment into the pregnancy period. It is interesting that 48% received treatment until the 12th gestational week and 12% continued treatment until delivery.
How does treatment influence outcome?
Increases pregnancy rate
Reduces rate of abortion
For the full survey report, please log into the following link at the IVF-Worldwide website:
On behalf of the IVF-Worldwide team and the of the website, we would like to take this opportunity to thank all the centers that participated in the survey by adding to international knowledge, as this could be of use around the world.
Please contribute to the survey which is currently posted on the website
You may use the attached logo in your website in order to provide the link:
Profs. Zeev Shoham and Milton Leong