Micheline Misrahi

Micheline Misrahi, Professor of Biochemistry and Molecular Biology Faculty of Medicine. University Paris-South Molecular Genetics of Reproductive and Metabolic diseases
Bicetre Hospital,France.
MD PhD: Medical Faculty Paris South 11, PhD in Biochemistry and Molecular Biology University Paris 6

FIELD OF INTEREST :

Molecular and cellular mechanisms in Reproductive and Thyroid Endocrinology.
Nuclear receptors, membrane receptors. Genetics of Infertility. Primary ovarian failure.

-RECENT RESPONSABILITIES IN RESEARCH EVALUATION AND TEACHING:

• Director of the "Cell Signalling, Neurosciences, Endocrinology and Reproduction" Doctoral School, PhD program, Paris South
• Member of the Scientific Council of the Paris-South Faculty of Medicine
• Coordinator of the National Institute of Health and Medical Research-. INSERM Endocrinology-Diabetes Interface Committee
• Member of the National Institute of Health and Medical Research- Committee of the National Research Program on Endocrinology and Reproduction
• Member of the Scientific Council of the National Institute for Health and Medical Research-INSERM.
• Expert at the French National Agency of Drug Safety
• Expert at the United State-Israel Bi-national Science Foundation

MAIN SCIENTIFIC RESULTS AND CONTRIBUTIONS

• Cloning of the human progesterone cDNA and of the human gene
• Cloning of the porcine LH/CG receptor and of the human gene.
• Cloning of the human TSH receptor cDNA and of the human gene
• Description of the basolateral targeting signals of the LH, FSH and TSH receptors
• Descrition of a new signalling pathway involved in TSHR trafficking involving hScriB
• Description of a two steps mecanism involved in the cleavage and shedding of the TSH receptor.
• Development of an ELISA test for the study of neutral and functional auto-antibodies directed against the TSH receptor.
• Description of loss of function and constitutive mutations of the TSH receptor in congenital hypothyroidism and non immune hyperthyroidism
• Description of the first genetic cause of non syndromic hypogonadotropic hypogonadism with mutations of the GnRH receptor
• Description the first genetic cause of familial Spontaneous Ovarian Hyperstimulation Syndrome with broadening specificity of the FSH receptor.
• Description of complete or partial genetic defects of the FSH receptor in Primary Ovarian Failure .
• Description of male infertility with mutant Luteinizing hormone.

PRESENTLY

Mainly involved in the genetic diagnosis of National Reference Centres in France focusing in male or female Infertility and Metabolic diseases and in International collaborations in this field.

More than 100 publications in the field with the main work published in Science, Nature, PNAS, New England Journal of Medicine, JAMA.
. Citations : more than 6000 .