Cumulus cell genomics and its predictive value


Speaker:

Samir Hamamah,France

 

 

Speaker BIO:

hamamahProfessor in Reproductive Medicine
Medical school and University-hospital of Montpellier, France

Chair: Reproductive Biology department
Chair: ART/PGD Division at Arnaud de Villeneuve hospital, Montpellier
Head: INSERM U 1203 ' Early embryo development and pluripotency’
Member of national council of AIDS

Research Field:
Gene expression profiles of human cumulus–oocyte complexes, early embryo and endometrial cells, RNA profiles on the genomic scale, and identifying specific transcripts using DNA chips, and Embryo stem cells and hiPS.

Publications in refereed journals: more 150
Books chapters: 50
Books: 10
(Male Gametes: Production and Quality; Epididymis: its Role and Importance in Male Infertility, Male Infertility for Motility Disorders: etiological factors and treatment, Ovocyte et Embryon: de la Physiologie à la Pathologie, Médecine et Biologie de la Reproduction, Médecine et Biologie du Développement).
Invited speaker to national and international scientific meetings: 300

 

 

Overview

An enormous amount of knowledge about the human oocyte and CCs have been generated over the last years, due in part to the recent advances in gene expression technologies using microarray, CGH array and high-fidelity RNA amplification.
Numerous small endogenous non-coding transcripts, termed microRNAs (miRNAs), have been found to execute key functions in silencing expression of specific target genes in plant, animal and human systems.

Changes in miRNA expression profiles have been linked to pathologies such as cancer and infertility: female mice with global miRNA deficiency are sterile from several causes, including defects in oocyte function. In addition, the messenger RNA (mRNA) expression in mice and bovine during oogenesis shows that a large proportion of maternal genes are under the control of miRNAs. Thus, miRNA profiling offers an effective means of acquiring novel and valuable information regarding the regulation of transcripts involved in human reproduction.

The miRNAs study of oocyte-cumulus complex offers a promising opportunity, by a non-invasive method, to evaluate ovarian failure and pregnancy outcome